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Research and Clinical Studies

To support the growing body of research studying the efficacy of cognitive training, HappyNeuron Pro’s scientific team partners with research institutions worldwide to explore how HappyNeuron Pro helps with various conditions.

Below is a continually updated list of completed and ongoing studies using HappyNeuron Pro.

This page is for information only. Our goal is to help the entire digital therapeutic industry continue the research into the best way to care for individuals’ cognition. HappyNeuron does not yet sell any products or treatment tools that are FDA approved. If you are interested in using HappyNeuron in your research, please see our research offer.

Search (Topic, Authors, Institutions, etc.):
Status:
2014
Increased activation in Broca’s area after cognitive remediation in schizophrenia
Completed
Schizophrenia
fMRI
+
Institutions:
Switzerland
Lausanne Hospital
Investigators:
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey
Size:
16 Participants
Publication:
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca’s area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209.
–
2008
2011
Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial
Completed
Schizophrenia
+
Institutions:
France
Le Vinatier Hospital – Bron, Cognitive Neuroscience Centre – Lyon, Sainte-Anne Hospital – Paris
Investigators:
Nicolas Franck
Size:
280 Participants
Publication:
Franck N, Duboc C, Sundby C, et al. Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial. Schizophr Res. 2013;147(1):68‐74. doi:10.1016/j.schres.2013.03.009
–
2020
2021
Promoting cognitive health in schizophrenia during and after the COVID-19 pandemic: A national collaborative effort to implement online psychological interventions.
In Progress
Schizophrenia
+
Institutions:
Canada
Douglas Institute in Montréal, Royal’s Institute of Mental Health Research in Ottawa, Kingston Health Sciences Centre, Ontario Shores Centre for Mental Health Sciences in Toronto, Vancouver Coastal Health/UBC
Investigators:
Martin Lepage, Synthia Guimond, Michael Bodnar, Christopher Bowie, Michael Best, Todd Woodward, Mahesh Menon
Size:
100 Participants
–
2020
2024
Efficacy of Personalizing Cognitive Remediation for Schizophrenia by Targeting Impairments in Early Auditory Processing
In Progress
Schizophrenia
+
Institutions:
USA
Columbia University, NIMH
Investigators:
Alice Medalia, Alice Saperstein, Daniel Javitt, Min Qian
Size:
200 Participants
Trial Registration:
See Registration
–
2020
2021
A Measure of the Efficacy of Cognitive Remediation Therapy in an Inpatient Setting
In Progress
Schizophrenia
Bipolar
+
Institutions:
Canada
Saskatchewan Health Authority
Investigators:
Brent Nixon, Anne Pleydon, Christine Tait, Kingsley Nwachukwu, Fiyinfoluwa Peluola, Mansfield Mela
Size:
48 Participants
–
2019
2021
Improving Mental Functioning in Patients With Schizophrenia with a Drug and a Computerized Cognitive Training
In Progress
Schizophrenia
Drug
+
Institutions:
World
Boehringer Ingelheim
Investigators:
40 Sites in 6 countries
Size:
200 Participants
Trial Registration:
See Registration
–
2018
2021
Examine the effects of prolonged cognitive remediation on sustaining cognitive gains and functional recovery in schizophrenia.
In Progress
Schizophrenia
+
Institutions:
Singapore
Institute of Mental Health, Singapore Institute of Technology
Investigators:
Ho New Fei, Sim Kang Jimmy, Chee Keong Lee, Chen Guoyang, Wang Mingyuan, Suhailah Bte Abd Shukor, Daniel Poremski
Size:
45 Participants
–
2017
2021
Restoration of Cognitive Function With TDCS and Training in Schizophrenia
In Progress
Schizophrenia
tDCS
+
Institutions:
USA
Department of Veterans Affairs Office of Research and Development, Minneapolis VA Health Care System, Minneapolis
Investigators:
Tasha Marie Nienow
Size:
110 Participants
Trial Registration:
See Registration
–
2016
2018
An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders.
Completed
Schizophrenia
+
Institutions:
Canada
Toronto Centre for Addiction and Mental Health, and Department of Psychology, Queen’s University, Kingston ON
Investigators:
Best MW, Milanovic M, Shamblaw AL, Muere A, Lambe LJ. Hong IK, Haque MK, Bowie CR.
Size:
70 Participants
Publication:
Best MW, Milanovic M, Shamblaw AL, et al. An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders [published online ahead of print, 2019 Feb 15]. Int J Psychophysiol. 2019;S0167-8760(18)30863-8. doi:10.1016/j.ijpsycho.2019.02.004
–
2016
2018
A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning.
Completed
Schizophrenia
+
Institutions:
Canada
Department of Psychology and Department of Psychiatry, Queen’s University, Kingston, ON
Investigators:
Best MW, Milanovic M, Iftene F, Bowie CR
Size:
70 Participants
Trial Registration:
See Registration
Publication:
Best MW, Milanovic M, Iftene F, Bowie CR. A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning. Am J Psychiatry. 2019;176(4):297‐306. doi:10.1176/appi.ajp.2018.18070849
–
2016
2019
Randomized controlled trial of the GT1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia
Completed
Drug
Schizophrenia
+
Institutions:
USA
Yale University
Investigators:
John H. Krystal
Size:
80 Participants
Trial Registration:
See Registration
Publication:
Toral S. Surti, Mohini Ranganathan, Jason K. Johannesen, Ralitza Gueorguieva, Emma Deaso, Joshua G. Kenney, John H. Krystal, Deepak Cyril D’Souza. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research, Volume 256, 2023, Pages 36-43
–
2014
2017
Motivation and engagement during cognitive training for schizophrenia spectrum disorders
Completed
Schizophrenia
+
Institutions:
Canada
Department of Psychology, Queen’s University, Kingston, ON
Investigators:
Michael W.Best, Melissa Milanovic, Tanya Tran, Pauline Leung, Robyn Jackowich, Stéphanie Gauvin, Talia Leibovitz, Christopher R.Bowie
Size:
38 Participants
Publication:
Best MW, Milanovic M, Tran T, et al. Motivation and engagement during cognitive training for schizophrenia spectrum disorders. Schizophr Res Cogn. 2019;19:100151. Published 2019 May 23. doi:10.1016/j.scog.2019.100151
–
2014
2019
Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia
In Progress
Schizophrenia
+
Institutions:
Canada
University of British Columbia
Investigators:
Todd Woodward
Size:
75 Participants
–
2013
2015
Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia
Completed
Schizophrenia
Social Cognition
+
Institutions:
Canada
McGill University Psychiatry Department
Investigators:
Philippe-Olivier Harvey, Martin Lepage, Vickie Auclair
Size:
40 Participants
Publication:
No publication
–
2010
2011
Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia
Completed
Schizophrenia
+
Institutions:
Canada
Queen’s University, Kingston, ON
Investigators:
Christopher Bowie
Size:
30 Participants
Publication:
Bowie CR, McGurk SR, Mausbach B, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real-world behavior. Am J Psychiatry. 2012;169(7):710‐718. doi:10.1176/appi.ajp.2012.11091337
–
2006
2008
Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia.
Completed
Schizophrenia
+
Institutions:
Switzerland
Lausanne Hospital
Investigators:
Pascal Vianin
Size:
28 Participants
Publication:
Vianin, Pascal & Deppen, Patricia & Croisile, Bernard & Tarpin-Bernard, Franck & Sarrazin-Bruchez, P. & Dukes, R. & Grillon, M.L.. (2010). Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. J Cogn Rehabil. 28.
–

Treating Brain Injuries in Colorado

HappyNeuron Pro is very elegant because it actually pinpoints cognitive areas and it gives really strong stimulus items and that’s how you actually build cognitive functions. 

Dr. Mary Ann Keatley, Ph.D., CCC,
Brain Injury Hope Foundation

Read her Case Study →

Bridging the Brain and the Classroom ​

Every kid needs to be doing HappyNeuron Pro. Every school needs to be working on these skills. Every school in America should have a cognitive skill curriculum.

Kyra Minichan, M.A., CCC-SLP
The Cognitive Emporium

Read her Case Study →

Personalizing Brain Injury Support

 HappyNeuron Pro has allowed us to have a structure so we could underpin the client’s day and start their day with it. HappyNeuron Pro allowed us to engage with clients by allowing us to look at their scores and have a conversation around that.

Natalie Mackenzie, MSc, CPCRT, CBIST
BIS Services (Brain Injury Support + Cognitive Rehabilitation)

Read her Case Study →

Making Cognitive Remediation
Therapy Dynamic

Clients never get to a point where they are bored, because I have a lot of flexibility that way to keep them challenged and keep them moving.

 Debra Bushong, MS, LPC-S
HOPE program, UT Southwestern Medical Center

Read her Case Study →

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