Research and Clinical Studies

To support the growing body of research studying the efficacy of cognitive training, HappyNeuron Pro’s scientific team partners with research institutions all around the world to study how HappyNeuron Pro helps with a variety of conditions.

Below is a list of some completed and ongoing studies using HappyNeuron Pro.

If you are interested in conducting a study with HappyNeuron Pro, please contact us.

Search (Topic, Authors, Institutions, etc.):
Status:
2015
2016
«Cognitus & Moi»: A Computer-Based Cognitive Remediation Program for Children with Intellectual Disability
Completed
Intellectual disability
Children
+
Institutions:
France
Centre Hospitalier le Vinatier, Center of Cognitive Neuroscience, CNRS, University Lyon 1
Investigators:
Caroline Demily, Caroline Rigard, Élodie Peyroux, Gabrielle Chesnoy-Servanin, Aurore Morel, Nicolas Franck
Size:
30 Participants
-
2014
Increased activation in Broca’s area after cognitive remediation in schizophrenia
Completed
Schizophrenia
fMRI
+
Institutions:
Switzerland
Lausanne Hospital
Investigators:
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey
Size:
16 Participants
-
2011
2013
Cognitive Remediation for Treatment Resistant Depression
Completed
Depression
+
2008
2011
Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial
Completed
Schizophrenia
+
Institutions:
France
Le Vinatier Hospital - Bron, Cognitive Neuroscience Centre - Lyon, Sainte-Anne Hospital - Paris
Investigators:
Nicolas Franck
Size:
280 Participants
-
2004
2006
MNESIS Project – Using the internet as a means of social integration and cognitive stimulation in a residential unit for elderlies
Completed
Geriatrics
+
2019
2021
Activation therapy for the treatment of inpatients with depression – protocol for a randomised control trial compared to treatment as usual
In Progress
Depression
+
Institutions:
New Zealand
University of Otago, Christchurch
Investigators:
Ian RE Averill, Ben Beaglehole, Katie M. Douglas, Jennifer Jordan, Marie T. Crowe, Maree Inder,Cameron J. Lacey, Christopher M. Frampton, Christopher R. Bowie and Richard J. Porter
Size:
170 Participants
-
2019
Is social cognitive training efficient in autism? A pilot single-case study using the RC2S+ program
Completed
Social Cognition
Autism
+
Institutions:
France
Le Vinatier hospital, Université de Lyon, Institut des Sciences Cognitives, Lyon
Investigators:
Elodie Peyroux, Nicolas Franck
Size:
1 Participants
-
2019
2021
Improving Mental Functioning in Patients With Schizophrenia with a Drug and a Computerized Cognitive Training
In Progress
Schizophrenia
Drug
+
Institutions:
World
Boehringer Ingelheim
Investigators:
40 Sites in 6 countries
Size:
200 Participants
Trial Registration:
See Registration
-
2018
2019
An Evaluation of the Effectiveness and Feasibility of a Cognitive Remediation Program in a Residential Substance Use Treatment Facility
In Progress
Addiction
+
Institutions:
Australia
Wattlegrove Rehab Program, University of Queensland, Lives lived well
Investigators:
Leanne Hides, Julaine Allan, Anna Thompson, Frances Dark
Size:
65 Participants
Publication:
Pending
-
2018
2021
Can multitasking performance of older adults in close-to-real-life scenarios be improved?
In Progress
Multitasking
Geriatrics
+
Institutions:
Germany
Technical University of Chemnitz
Investigators:
Claudia Voelcker-Rehage, Otmar Bock, Konstantin Wechsler
Size:
150 Participants
-
2018
2021
Examine the effects of prolonged cognitive remediation on sustaining cognitive gains and functional recovery in schizophrenia.
In Progress
Schizophrenia
+
Institutions:
Singapore
Institute of Mental Health, Singapore Institute of Technology
Investigators:
Ho New Fei, Sim Kang Jimmy, Chee Keong Lee, Chen Guoyang, Wang Mingyuan, Suhailah Bte Abd Shukor, Daniel Poremski
Size:
45 Participants
-
2018
2022
Reducing delirium and dementia risk: A cognitive training intervention of older adults undergoing elective coronary artery bypass grafting surgery
In Progress
Surgery
+
Institutions:
Australia
Cognitive Ageing and Impairment Neurosciences Laboratory (CAIN) University of South Australia
Investigators:
Danielle Greaves, Hannah Keage, Peter Psaltis, Ashleigh Smith, Michael Worthington, Alice Bourke, Daniel Davis, Amit Lampit, Michael Valenzuela
Size:
120 Participants
-
2017
2018
Experiences With a Cognitive Rehabilitation Program for Five Female Breast Cancer Survivors: A Focus Group Study
Completed
Cancer
Focus Group
+
2017
2019
Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.
Completed
Bipolar
+
Institutions:
Denmark
Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet
Investigators:
Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW
Size:
58 Participants
Trial Registration:
See Registration
-
2017
2018
The effects of computer based cognitive rehabilitation in patients with symptoms of visuospatial neglect or hemianopsia after stroke.
Completed
Stroke
+
Institutions:
Denmark
Bispebjerg Hospital, Department of Neurology, Copenhagen
Investigators:
Svaerke K, Omkvist K, Havsteen I, Christensen H
Size:
14 Participants
-
2017
2021
Restoration of Cognitive Function With TDCS and Training in Schizophrenia
In Progress
Schizophrenia
tDCS
+
Institutions:
USA
Department of Veterans Affairs Office of Research and Development, Minneapolis VA Health Care System, Minneapolis
Investigators:
Tasha Marie Nienow
Size:
110 Participants
Trial Registration:
See Registration
-
2017
2018
A Comparison of two Computer-Assisted Cognitive Training Program Outcomes for Breast Cancer Survivors: A Pilot Study
Completed
Cancer
+
Institutions:
USA
Department of Occupational Therapy and Rehabilitation Sciences, The University of Texas Medical Branch
Investigators:
Theresa Smith, Karen Ratcliff
Size:
20 Participants
-
2016
2018
Clinical response to treatment in inpatients with depression correlates with changes in activity levels and psychomotor speed
Completed
Depression
+
Institutions:
New Zealand
University of Otago, Christchurch
Investigators:
Ian RE Averill, Marie Crowe, Chris M Frampton, Ben Beaglehole, Cameron J Lacey, Jennifer Jordan, Lynere D Wilson, Katie M Douglas and Richard J Porter
Size:
24 Participants
-
2016
2018
An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders.
Completed
Schizophrenia
+
Institutions:
Canada
Toronto Centre for Addiction and Mental Health, and Department of Psychology, Queen's University, Kingston ON
Investigators:
Best MW, Milanovic M, Shamblaw AL, Muere A, Lambe LJ. Hong IK, Haque MK, Bowie CR.
Size:
70 Participants
-
2016
2018
A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning.
Completed
Schizophrenia
+
Institutions:
Canada
Department of Psychology and Department of Psychiatry, Queen's University, Kingston, ON
Investigators:
Best MW, Milanovic M, Iftene F, Bowie CR
Size:
70 Participants
Trial Registration:
See Registration
-
2016
2017
Effects of simultaneous aerobic and cognitive training on executive functions, cardiovascular fitness and functional abilities in older adults with mild cognitive impairment
Completed
MCI
Physical Activity
+
Institutions:
France
University Paris Sud, Institut Universitaire de Gériatrie de Montréal, University Hospital of Amiens-Picardie, University of Poitiers
Investigators:
Laure Combourieu Donnezan, Alexandra Perrot, Sylvie Belleville, Frédéric Bloch, Gilles Kemoun
Size:
69 Participants
-
2016
2017
Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial
Completed
SMI
Employment
+
Institutions:
Australia
University of Sydney, Macquarie University
Investigators:
Anthony WF Harris, Tanya Kosic, Jean Xu, Chris Walker, William Gye, Antoinette Redoblado Hodge
Size:
86 Participants
Trial Registration:
See Registration
-
2016
2018
Helping people with a mental illness obtain work: the Health Optimisation Program for Employment
Completed
Mental Illness
Employment
+
Institutions:
Australia
St Vincent's Hospital, Melbourne
Investigators:
David Castle, Andrea Phillipou, Gaye Moore, Caroline Crosse AM, Anne Miles
Size:
100 Participants
-
2016
2018
The role of cognitive rehabilitation in patients with type 1 diabetes
Completed
Diabetes
+
2016
2019
Translational Neuroscience Optimization of GlyT1 Inhibitor
In Progress
Drug
Schizophrenia
+
Institutions:
USA
Yale University
Investigators:
John H. Krystal
Size:
80 Participants
Trial Registration:
See Registration
Publication:
Pending
-
2016
2019
Exploring cognitive training as a non-pharmaceutical therapeutic intervention for people with Huntington’s disease
Completed
Huntington’s disease
+
Institutions:
UK
Cardiff University in the Cardiff Huntington’s Disease Research Centre
Investigators:
Emma Yhnell, Hannah Furby, Rachel S. Lowe, Lucy C. Brookes-Howell, Cheney J. G. Drew, Rebecca Playle, Gareth Watson, Claudia Metzler-Baddeley, Anne E. Rosser & Monica E. Busse
Size:
30 Participants
Trial Registration:
See Registration
-
2016
2017
Evaluation of cognitive tele-rehabilitation program for children with Attention Deficit Hyperactivity Disorder
Completed
ADHD
Children
+
Institutions:
Spain
Bio functional Studies Institute – Universidad Complutense (Madrid)
Investigators:
Elimelech Duarte, Jesus Alvarado, Alejandra Koeneke
Size:
100 Participants
Publication:
No Publication
-
2015
2022
Prevention of Alzheimer’s Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression
In Progress
Alzheimer's Disease
tDCS
MCI
+
Institutions:
Canada
Centre for Addiction and Mental Health, Queen's University, Baycrest Centre for Geriatric Care
Investigators:
Benoit Mulsant
Size:
500 Participants
Trial Registration:
See Registration
-
2015
2017
Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning.
Completed
SMI
EEG
Executive Functionning
+
Institutions:
Canada
Toronto Centre for Addiction and Mental Health, and University of Toronto Department of Psychiatry
Investigators:
Best MW, Gale D, Tran T, Haque MK, Bowie CR
Size:
25 Participants
-
2015
2018
A comparison of compensatory and restorative cognitive interventions in early psychosis.
Completed
Psychosis
+
Institutions:
Canada
Toronto Centre for Addiction and Mental Health, and University of Toronto Department of Psychiatry
Investigators:
Kidd SA, Herman Y, Virdee G, Bowie CR, Velligan D, Plagiannakos C, Voineskos A.
Size:
56 Participants
Trial Registration:
See Registration
-
2015
2018
Evaluation of Dallas Metrocare’s Enhanced Program for Early Psychosis (ePEP)
Completed
Psychosis
+
Institutions:
USA
UT Southwestern Medical Center
Investigators:
Carol North, Ana Stan, Debra Bushong, Draper Bushanan
Size:
90 Participants
Presentation:
Presentation
-
2015
2020
The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial
Completed
Psychosis
+
Institutions:
Denmark
Psychiatric Center Copenhagen
Investigators:
Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft
Size:
126 Participants
Trial Registration:
See Registration
-
2014
2017
Motivation and engagement during cognitive training for schizophrenia spectrum disorders
Completed
Schizophrenia
+
Institutions:
Canada
Department of Psychology, Queen's University, Kingston, ON
Investigators:
Michael W.Best, Melissa Milanovic, Tanya Tran, Pauline Leung, Robyn Jackowich, Stéphanie Gauvin, Talia Leibovitz, Christopher R.Bowie
Size:
38 Participants
-
2014
2019
Manualized group cognitive-behavioral therapy for social anxiety in first episode psychosis: A randomized controlled trial
In Progress
Psychosis
+
Institutions:
Canada
Douglas Mental Health University Insitute, Montreal, QC & Department of Psychiatry, McGill University, Montréal QC
Investigators:
Martin Lepage, Ashol K. Malla, Philippe-Olivier Harvey, Christopher Bowie
Size:
120 Participants
Trial Registration:
See Registration
-
2014
2019
Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia
In Progress
Schizophrenia
+
Institutions:
Canada
University of British Columbia
Investigators:
Todd Woodward
Size:
75 Participants
-
2014
2016
Cognitive Training protocols in people with Chronic Pain
Completed
Chronic Pain
+
Institutions:
Australia
School of Psychological Sciences, Monash University; and Caufiled Pain Management and Research Center, Caulfield Hospital
Investigators:
Melita Giummarra, Nellie Georgiou-Karistianis, Stephen Gibson, Katharine Baker
Size:
50 Participants
-
2014
2016
Individualized Metacognitive Training (MCT+) Reduces Delusional Symptoms in Psychosis: A Randomized Clinical Trial
Completed
Psychosis
+
2014
2015
Facilitating success for people with mental health issues in a college through cognitive remediation therapy and social and emotional learning
Completed
Mental Health
Academic Success
+
Institutions:
Canada
CPLS - George Brown College - Saint James Campus - Toronto, Department of Medical Sciences - University of Western Ontario
Investigators:
Jaswant Kaur Bajwa, Alex Irwin
Size:
21 Participants
-
2014
2017
Cognitive training to improve language comprehension for seniors?
Completed
Geriatrics
+
Institutions:
Germany
Jean-Uhrmacher Institut für klinische HNO-Forschung, Klinik und Poliklinik für Neurologie der Uniklinik Köln, Lehrstuhl für Pädagogik und Didaktik hörgeschädigter Menschen
Investigators:
Magdalene Ortmann, Harmut Meister, Josef Kessler, Thomas Kaul
Size:
50 Participants
Publication:
No Publication
-
2013
2015
Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia
Completed
Schizophrenia
Social Cognition
+
Institutions:
Canada
McGill University Psychiatry Department
Investigators:
Philippe-Olivier Harvey, Martin Lepage, Vickie Auclair
Size:
40 Participants
Publication:
No publication
-
2013
2014
Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study
Completed
Hoarding Disorder
+
2012
Conditions for Maximizing Effects of 90 Days of Brain Training
Completed
General Population
+
Institutions:
France
Scientific Brain Training
Investigators:
Franck Tarpin-Bernard, Bernard Croisile
Size:
350 Participants
-
2011
2013
Action-based cognitive remediation for individuals with serious mental illnesses: Effects of real-world simulations and goal setting
Completed
SMI
+
2011
Increased employability of the unemployed aged 50+ through cognitive training?
Completed
Employment
+
Institutions:
Germany
Jacobs Center on Lifelong Learning & Research Institutional Development, Jacobs University Bremen
Investigators:
B. Godde, C. M. G. Noack, C. Windisch & C. Voelcker-Rehage
Size:
87 Participants
Presentation:
Presentation
-
2010
2011
Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia
Completed
Schizophrenia
+
2007
Alzheimer’s patients maintain cognitive skills and improve self confidence
Completed
Alzheimer's Disease
+
Institutions:
France
Sophia’s Gardens, Alzheimer’s disease clinic, Castelnau-le-Lez
Investigators:
Dr. Foare
Size:
47 Participants
-
2007
Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans
Completed
General Population
fMRI
+
Institutions:
USA
Johnny Orr Memory Center, Iowa Health System, Funded by the Center for Disease Control
Investigators:
Robert Bender III, David Michael, Derek Campbell, Charles DePena
-
2006
2008
Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia.
Completed
Schizophrenia
+
2006
Memory Stimulation. Which scientific benefits? Which exercises?
Completed
Geriatrics
+
Institutions:
France
Scientific Brain Training
Investigators:
Bernard Croisile et al
Size:
39 Participants
-
2001
2002
Transferability of Cognitive Training to every-day activities (AKA King 64)
Completed
Children
+
Institutions:
France
EMC laboratory (Université Lyon II – CNRS)
Investigators:
Michel Noir, Ph.D
Size:
117 Participants
Publication:
Thesis
-

Page last updated on Jun 11,2020

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I have seen positive behavioral changes in the people that I work with. The staff and clients love HappyNeuron Pro.

Dyana HagenB.S.W.InterCommunity Inc.’s Common Ground Learning CenterEast Hartford, CT, USA

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“[people considering using HappyNeuron Pro] should go for it. It’s worth the investment”

Ruth MwauraClinical PsychologistThalia PsychotherapyNairobi, Kenya

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Kristin HoffmanRehab Specialist & SLPiN2LDenver, CO, USA

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Every kid needs to be doing HappyNeuron Pro. Every school needs to be working on these skills. Every school in America should have a cognitive skill curriculum..

Kyra MinichanSLPThe Cognitive EmporiumHendersonville, TN – USA

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Our favorite thing is to be able to break down into core cognitive domains, knowing every task the patient is doing touches upon overlapping cognitive skills, and it gives participants a sense of what skills they are working on.

Vocational CoachWISE EmploymentMelbourne – Australia

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This program is something that really can benefit the well-being of the clients we serve. It gives us more resources and tools to help people.

Lisa RaeDirector of Business DevelopmentIntegrative Group Psychology ServicesChicago, IL – USA

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“The team at HappyNeuron understands our customers’ needs and how iN2L can fit as a solution. It is an important aspect of any relationship, but in situations like this, it is particularly valuable.”

Chris KrauseDir. of Research and OutcomeiN2LDenver, CO, USA

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It was just enjoyable to see the results right at the moment. So once a patient is done with the group, I was able to get the results immediately and see what they did well on and what needed to still be improved. HappyNeuron Pro is just easy and accessible.

Hector SiglerDirector of OperationsFamily Recovery CenterLantana, FL – USA

We love this program! One of my success stories was the man who had a stroke. As a matter of fact, everybody noticed his progress after using HappyNeuron Pro.

Laura ArgentineLCSWIntegrative Group Psychology ServicesChicago, IL – USA

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