Research and Clinical Studies

To support the growing body of research studying the efficacy of cognitive training, HappyNeuron Pro’s scientific team partners with research institutions worldwide to explore how HappyNeuron Pro helps with various conditions.

Below is a continually updated list of completed and ongoing studies using HappyNeuron Pro.

This page is for information only. Our goal is to help the entire digital therapeutic industry continue the research into the best way to care for individuals’ cognition. HappyNeuron does not yet sell any products or treatment tools that are FDA approved. If you are interested in using HappyNeuron in your research, please see our research offer.

2015
2016

«Cognitus & Moi»: A Computer-Based Cognitive Remediation Program for Children with Intellectual Disability

Completed

Intellectual disability

Children

Institutions:

France

Centre Hospitalier le Vinatier, Center of Cognitive Neuroscience, CNRS, University Lyon 1

Investigators:

Caroline Demily, Caroline Rigard, Élodie Peyroux, Gabrielle Chesnoy-Servanin, Aurore Morel, Nicolas Franck

Size:

30 Participants

Publication:

Demily, Caroline & Rigard, Caroline & Peyroux, Élodie & Chesnoy-Servanin, Gabrielle & Morel, Aurore & Franck, Nicolas. (2016). «Cognitus & Moi»: A Computer-Based Cognitive Remediation Program for Children with Intellectual Disability. Frontiers in psychiatry. 7. 10. 10.3389/fpsyt.2016.00010.

–

2014

Increased activation in Broca’s area after cognitive remediation in schizophrenia

Completed

Schizophrenia

fMRI

Institutions:

Switzerland

Lausanne Hospital

Investigators:

Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey

Size:

16 Participants

Publication:

Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca’s area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209.

–

2011
2013

Cognitive Remediation for Treatment Resistant Depression

Completed

Depression

Institutions:

Canada

Queen’s University, Kingston, ON

Investigators:

Christopher Bowie

Publication:

Bowie CR, Gupta M, Holshausen K, Jokic R, Best M, Milev R. Cognitive remediation for treatment-resistant depression: effects on cognition and functioning and the role of online homework. J Nerv Ment Dis. 2013;201(8):680‐685. doi:10.1097/NMD.0b013e31829c5030

–

2008
2011

Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial

Completed

Schizophrenia

Institutions:

France

Le Vinatier Hospital – Bron, Cognitive Neuroscience Centre – Lyon, Sainte-Anne Hospital – Paris

Investigators:

Nicolas Franck

Size:

280 Participants

Publication:

Franck N, Duboc C, Sundby C, et al. Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial. Schizophr Res. 2013;147(1):68‐74. doi:10.1016/j.schres.2013.03.009

–

2004
2006

MNESIS Project – Using the internet as a means of social integration and cognitive stimulation in a residential unit for elderlies

Completed

Geriatrics

Institutions:

France

Lyon 2 University, Lyon INSA (ICTT), Medica-France

Investigators:

Bobillier Chaumon, Marc-Eric & Michel, Christine & Tarpin-Bernard, Franck & Croisile, Bernard

Publication:

Bobillier Chaumon, Marc-Eric & Michel, Christine & Tarpin-Bernard, Franck & Croisile, Bernard. (2014). Can ICT improve the quality of life of elderly adults living in residential home care units (RHCU)? From actual impacts to hidden artifacts. Behaviour and Information Technology. 33. 10.1080/0144929X.2013.832382.

–

2020
2021

Promoting cognitive health in schizophrenia during and after the COVID-19 pandemic: A national collaborative effort to implement online psychological interventions.

In Progress

Schizophrenia

Institutions:

Canada

Douglas Institute in Montréal, Royal’s Institute of Mental Health Research in Ottawa, Kingston Health Sciences Centre, Ontario Shores Centre for Mental Health Sciences in Toronto, Vancouver Coastal Health/UBC

Investigators:

Martin Lepage, Synthia Guimond, Michael Bodnar, Christopher Bowie, Michael Best, Todd Woodward, Mahesh Menon

Size:

100 Participants

–

2020
2024

Efficacy of Personalizing Cognitive Remediation for Schizophrenia by Targeting Impairments in Early Auditory Processing

In Progress

Schizophrenia

Institutions:

USA

Columbia University, NIMH

Investigators:

Alice Medalia, Alice Saperstein, Daniel Javitt, Min Qian

Size:

200 Participants

Trial Registration:

See Registration

–

2020
2021

A Measure of the Efficacy of Cognitive Remediation Therapy in an Inpatient Setting

In Progress

Schizophrenia

Bipolar

Institutions:

Canada

Saskatchewan Health Authority

Investigators:

Brent Nixon, Anne Pleydon, Christine Tait, Kingsley Nwachukwu, Fiyinfoluwa Peluola, Mansfield Mela

Size:

48 Participants

–

2020

Comparison of a standard computer‐assisted cognitive training program to a music enhanced program: A mixed methods study

Completed

Cancer

Music

Institutions:

USA

Texas Woman’s University

Investigators:

Theresa M. Smith, Wanyi Wang

Size:

25 Participants

Publication:

Smith, TM, Wang, W. Comparison of a standard computer‐assisted cognitive training program to a music enhanced program: A mixed methods study. Cancer Reports. 2020;e1325. https://doi.org/10.1002/cnr2.1325

–

2020
2022

Cognitive Remediation in Forensic Mental Health Care

In Progress

Forensics

Mental Heath

Institutions:

Canada

The Royal Ottawa Mental Health Centre

Investigators:

Patrizia Pezzoli, Michael Seto, Synthia Guimond, Sanjiv Gulati

Size:

30 Participants

Trial Registration:

See Registration

Presentation:

Abstract at the Cognitive Remediation Conference 2022

–

2019
2021

Activation therapy for the treatment of inpatients with depression – protocol for a randomised control trial compared to treatment as usual

In Progress

Depression

Institutions:

New Zealand

University of Otago, Christchurch

Investigators:

Ian RE Averill, Ben Beaglehole, Katie M. Douglas, Jennifer Jordan, Marie T. Crowe, Maree Inder,Cameron J. Lacey, Christopher M. Frampton, Christopher R. Bowie and Richard J. Porter

Size:

170 Participants

Presentation:

Averill, I.R.E., Beaglehole, B., Douglas, K.M. et al. Activation therapy for the treatment of inpatients with depression – protocol for a randomised control trial compared to treatment as usual. BMC Psychiatry 19, 52 (2019). https://doi.org/10.1186/s12888-019-2038-2

–

2019

Is social cognitive training efficient in autism? A pilot single-case study using the RC2S+ program

Completed

Social Cognition

Autism

Institutions:

France

Le Vinatier hospital, Université de Lyon, Institut des Sciences Cognitives, Lyon

Investigators:

Elodie Peyroux, Nicolas Franck

Size:

1 Participants

Publication:

Peyroux E, Franck N. Is social cognitive training efficient in autism? A pilot single-case study using the RC2S+ program. Neurocase. 2019;25(6):217‐224. doi:10.1080/13554794.2019.1666877

–

2019
2021

Improving Mental Functioning in Patients With Schizophrenia with a Drug and a Computerized Cognitive Training

In Progress

Schizophrenia

Drug

Institutions:

World

Boehringer Ingelheim

Investigators:

40 Sites in 6 countries

Size:

200 Participants

Trial Registration:

See Registration

–

2019
2021

Improving Cognitive Skills for People with Mental Illness to Increase Vocational and Psychosocial Outcomes: The Employ Your Mind Program

Completed

Severe Mental Illness

Employment

Institutions:

Autralia

St Vincent’s Hospital, Melbourne

Investigators:

Anne Miles, Caroline Crosse, Zoe Jenkins, Paul Morgan, Ellie Fossey, Carol Harvey, David Castle

Size:

32 Participants

Publication:

Miles, A., Crosse, C., Jenkins, Z. et al. Improving Cognitive Skills for People with Mental Illness to Increase Vocational and Psychosocial Outcomes: The Employ Your Mind Program. J. Psychosoc. Rehabil. Ment. Health (2021). https://doi.org/10.1007/s40737-021-00225-9

–

2019
2021

Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a

Completed

Multiple Sclerosis

Institutions:

Israel

Sheba Medical Center, Ramat Gan

Investigators:

Shay Menascu, Roy Aloni, Mark Dolev, David Magalashvili, Keren Gutman, Sapir Dreyer‑Alster, Franck Tarpin‑Bernard, Ran Achiron, Gil Harari and Anat Achiron

Size:

100 Participants

Publication:

Menascu, S., Aloni, R., Dolev, M. et al. Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a. J NeuroEngineering Rehabil 18, 175 (2021). https://doi.org/10.1186/s12984-021-00968-3

–

2019
2021

A randomised controlled trial of psychotherapy and cognitive remediation to target cognition in mood disorders

Completed

Bipolar

Mood

Institutions:

New Zealand

University of Otago, Christchurch

Investigators:

Katie M. Douglas,Samantha Groves,Marie T. Crowe,Maree L. Inder,Jennifer Jordan,Dave Carlyle,Hayley Wells,Ben Beaglehole,Roger Mulder,Cameron Lacey,Suzanne E. Luty,Kate Eggleston,Christopher M. A. Frampton,Christopher R. Bowie,Richard J. Porter

Size:

68 Participants

Publication:

Douglas, KM, Groves, S, Crowe, MT, et al. A randomised controlled trial of psychotherapy and cognitive remediation to target cognition in mood disorders. Acta Psychiatr Scand. 2022; 145: 278– 292. doi:10.1111/acps.13387

–

2018
2019

An Evaluation of the Effectiveness and Feasibility of a Cognitive Remediation Program in a Residential Substance Use Treatment Facility

In Progress

Addiction

Institutions:

Australia

Wattlegrove Rehab Program, University of Queensland, Lives lived well

Investigators:

Leanne Hides, Julaine Allan, Anna Thompson, Frances Dark

Size:

65 Participants

Presentation:

Poster presented in Nov 2019 at the Australasian Professional Society for Alcohol and other Drugs

Publication:

Pending

–

2018
2022

Training-induced plasticity of multitasking in everyday-like motor behavior

In Progress

Multitasking

Geriatrics

Institutions:

Germany

Technical University of Chemnitz, University of Münster

Investigators:

Claudia Voelcker-Rehage, Otmar Bock, Melanie Mack

Size:

150 Participants

Trial Registration:

See Registration

Presentation:

Presentation

–

2018
2021

Examine the effects of prolonged cognitive remediation on sustaining cognitive gains and functional recovery in schizophrenia.

In Progress

Schizophrenia

Institutions:

Singapore

Institute of Mental Health, Singapore Institute of Technology

Investigators:

Ho New Fei, Sim Kang Jimmy, Chee Keong Lee, Chen Guoyang, Wang Mingyuan, Suhailah Bte Abd Shukor, Daniel Poremski

Size:

45 Participants

–

2018
2019

Neuropsychological management of multiple sclerosis: evaluation of a supervised and customized cognitive rehabilitation program for self-used at home (SEPIA): protocol for a randomized controlled trial

Completed

Multiple Sclerosis

Institutions:

France

Centre Hospitalier Universitaire de Caen Normandie

Investigators:

Caroline Harand, France Daniel, Audrey Mondou, Damien Chevanne, Christian Creveuil, Gilles Defer

Size:

40 Participants

Trial Registration:

See Registration

Publication:

Harand, C., Daniel, F., Mondou, A. et al. Neuropsychological management of multiple sclerosis: evaluation of a supervised and customized cognitive rehabilitation program for self-used at home (SEPIA): protocol for a randomized controlled trial. Trials 20, 614 (2019). https://doi.org/10.1186/s13063-019-3715-7

–

2017
2018

Experiences With a Cognitive Rehabilitation Program for Five Female Breast Cancer Survivors: A Focus Group Study

Completed

Cancer

Focus Group

Institutions:

USA

Texas Woman’s University, University of Texas

Investigators:

Theresa M. Smith, Karen Ratcliff, Rachel A. Perry

Size:

5 Participants

Publication:

Theresa M. Smith, Karen Ratcliff, Rachel A. Perry. Experiences With a Cognitive Rehabilitation Program for Five Female Breast Cancer Survivors: A Focus Group Study. Annals of International Occupational Therapy. 2019;2(4):152-159https://doi.org/10.3928/24761222-20190625-03

–

2017
2019

Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.

Completed

Bipolar

Institutions:

Denmark

Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet

Investigators:

Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW

Size:

58 Participants

Trial Registration:

See Registration

Publication:

Ott CV, Vinberg M, Bowie CR, et al. Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial [published correction appears in Trials. 2019 Apr 8;20(1):201]. Trials. 2018;19(1):487. Published 2018 Sep 12. doi:10.1186/s13063-018-2860-8

–

2017
2018

The effects of computer based cognitive rehabilitation in patients with symptoms of visuospatial neglect or hemianopsia after stroke.

Completed

Stroke

Institutions:

Denmark

Bispebjerg Hospital, Department of Neurology, Copenhagen

Investigators:

Svaerke K, Omkvist K, Havsteen I, Christensen H

Size:

14 Participants

Publication:

Svaerke KW, Omkvist KV, Havsteen IB, Christensen HK. Computer-Based Cognitive Rehabilitation in Patients with Visuospatial Neglect or Homonymous Hemianopia after Stroke. J Stroke Cerebrovasc Dis. 2019;28(11):104356. doi:10.1016/j.jstrokecerebrovasdis.2019.104356

–

2017
2021

Restoration of Cognitive Function With TDCS and Training in Schizophrenia

In Progress

Schizophrenia

tDCS

Institutions:

USA

Department of Veterans Affairs Office of Research and Development, Minneapolis VA Health Care System, Minneapolis

Investigators:

Tasha Marie Nienow

Size:

110 Participants

Trial Registration:

See Registration

–

2017
2018

A Comparison of two Computer-Assisted Cognitive Training Program Outcomes for Breast Cancer Survivors: A Pilot Study

Completed

Cancer

Institutions:

USA

Department of Occupational Therapy and Rehabilitation Sciences, The University of Texas Medical Branch

Investigators:

Theresa Smith, Karen Ratcliff

Size:

20 Participants

Publication:

Theresa M. Smith, Karen Ratcliff, A Comparison of two Computer-Assisted Cognitive Training Program Outcomes for Breast Cancer Survivors: A Pilot Study. Journal of Korean Society of Occupational Therapy 2019;27(3):145-156

–

2016
2018

Clinical response to treatment in inpatients with depression correlates with changes in activity levels and psychomotor speed

Completed

Depression

Institutions:

New Zealand

University of Otago, Christchurch

Investigators:

Ian RE Averill, Marie Crowe, Chris M Frampton, Ben Beaglehole, Cameron J Lacey, Jennifer Jordan, Lynere D Wilson, Katie M Douglas and Richard J Porter

Size:

24 Participants

Publication:

Averill, I. R., Crowe, M., Frampton, C. M., Beaglehole, B., Lacey, C. J., Jordan, J., … Porter, R. J. (2018). Clinical response to treatment in inpatients with depression correlates with changes in activity levels and psychomotor speed. Australian & New Zealand Journal of Psychiatry, 52(7), 652–659. https://doi.org/10.1177/0004867417753549

–

2016
2018

An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders.

Completed

Schizophrenia

Institutions:

Canada

Toronto Centre for Addiction and Mental Health, and Department of Psychology, Queen’s University, Kingston ON

Investigators:

Best MW, Milanovic M, Shamblaw AL, Muere A, Lambe LJ. Hong IK, Haque MK, Bowie CR.

Size:

70 Participants

Publication:

Best MW, Milanovic M, Shamblaw AL, et al. An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders [published online ahead of print, 2019 Feb 15]. Int J Psychophysiol. 2019;S0167-8760(18)30863-8. doi:10.1016/j.ijpsycho.2019.02.004

–

2016
2018

A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning.

Completed

Schizophrenia

Institutions:

Canada

Department of Psychology and Department of Psychiatry, Queen’s University, Kingston, ON

Investigators:

Best MW, Milanovic M, Iftene F, Bowie CR

Size:

70 Participants

Trial Registration:

See Registration

Publication:

Best MW, Milanovic M, Iftene F, Bowie CR. A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning. Am J Psychiatry. 2019;176(4):297‐306. doi:10.1176/appi.ajp.2018.18070849

–

2016
2017

Effects of simultaneous aerobic and cognitive training on executive functions, cardiovascular fitness and functional abilities in older adults with mild cognitive impairment

Completed

MCI

Physical Activity

Institutions:

France

University Paris Sud, Institut Universitaire de Gériatrie de Montréal, University Hospital of Amiens-Picardie, University of Poitiers

Investigators:

Laure Combourieu Donnezan, Alexandra Perrot, Sylvie Belleville, Frédéric Bloch, Gilles Kemoun

Size:

69 Participants

Publication:

Combourieu Donnezan, L., Perrot, A., Belleville, S., Bloch, Fréé., Kemoun, G., Effects of simultaneous aerobic and cognitive training on executive functions, cardiovascular fitness and functional abilities in older adults with mild cognitive impairment, Mental Health and Physical Activity (2018), doi: 10.1016/j.mhpa.2018.06.001.

–

2016
2017

Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial

Completed

SMI

Employment

Institutions:

Australia

University of Sydney, Macquarie University

Investigators:

Anthony WF Harris, Tanya Kosic, Jean Xu, Chris Walker, William Gye, Antoinette Redoblado Hodge

Size:

86 Participants

Trial Registration:

See Registration

Publication:

Harris AW, Kosic T, Xu J, Walker C, Gye W, Redoblado Hodge A. Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial. JMIR Ment Health. 2017;4(3):e30. Published 2017 Sep 20. doi:10.2196/mental.6982

–

2016
2018

Helping people with a mental illness obtain work: the Health Optimisation Program for Employment

Completed

Mental Illness

Employment

Institutions:

Australia

St Vincent’s Hospital, Melbourne

Investigators:

David Castle, Andrea Phillipou, Gaye Moore, Caroline Crosse AM, Anne Miles

Size:

100 Participants

Publication:

Castle D, Crosse C, Morgain D, et al. Helping people with a mental illness obtain work: the Health Optimisation Program for Employment. Australas Psychiatry. 2016;24(4):337‐341. doi:10.1177/1039856216654400

–

2016
2018

The role of cognitive rehabilitation in patients with type 1 diabetes

Completed

Diabetes

Institutions:

Russia

Siberian State Medical University Tomsk, Russian Ministry of Health

Investigators:

YG Samoilova, MV Matveeva, NG Zhukov

Size:

200 Participants

Publication:

Matveeva MV, Samoilova YG, Zhukova NG, Ratkina KR, Yakimovich IY. Raznye vidy reabilitatsii kognitivnoĭ disfunktsii u patsientov s sakharnym diabetom 2-go tipa [Different types of cognitive rehabilitation in patients with type 2 diabetes]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(8):12‐17. doi:10.17116/jnevro201911908112

–

2016
2019

Randomized controlled trial of the GT1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia

Completed

Drug

Schizophrenia

Institutions:

USA

Yale University

Investigators:

John H. Krystal

Size:

80 Participants

Trial Registration:

See Registration

Publication:

Toral S. Surti, Mohini Ranganathan, Jason K. Johannesen, Ralitza Gueorguieva, Emma Deaso, Joshua G. Kenney, John H. Krystal, Deepak Cyril D’Souza. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research, Volume 256, 2023, Pages 36-43

–

2016
2019

A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington’s disease (CogTrainHD)

Completed

Huntington’s disease

Institutions:

Cardiff University in the Cardiff Huntington’s Disease Research Centre

Investigators:

Emma Yhnell, Hannah Furby, Rachel S. Lowe, Lucy C. Brookes-Howell, Cheney J. G. Drew, Rebecca Playle, Gareth Watson, Claudia Metzler-Baddeley, Anne E. Rosser & Monica E. Busse

Size:

30 Participants

Trial Registration:

See Registration

Publication:

Yhnell, E., Furby, H., Lowe, R.S. et al. A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington’s disease (CogTrainHD). Pilot Feasibility Stud 6, 88 (2020). https://doi.org/10.1186/s40814-020-00623-z

–

2016
2017

Evaluation of cognitive tele-rehabilitation program for children with Attention Deficit Hyperactivity Disorder

Completed

ADHD

Children

Institutions:

Spain

Bio functional Studies Institute – Universidad Complutense (Madrid)

Investigators:

Elimelech Duarte, Jesus Alvarado, Alejandra Koeneke

Size:

100 Participants

Publication:

No Publication

–

2015
2022

Prevention of Alzheimer’s Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression

In Progress

Alzheimer’s Disease

tDCS

MCI

Institutions:

Canada

Centre for Addiction and Mental Health, Queen’s University, Baycrest Centre for Geriatric Care

Investigators:

Benoit Mulsant

Size:

500 Participants

Trial Registration:

See Registration

–

2015
2017

Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning.

Completed

SMI

EEG

Executive Functionning

Institutions:

Canada

Toronto Centre for Addiction and Mental Health, and University of Toronto Department of Psychiatry

Investigators:

Best MW, Gale D, Tran T, Haque MK, Bowie CR

Size:

25 Participants

Publication:

Best MW, Gale D, Tran T, Haque MK, Bowie CR. Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning. Schizophr Res. 2019;203:32‐40. doi:10.1016/j.schres.2017.08.052

–

2015
2018

A comparison of compensatory and restorative cognitive interventions in early psychosis.

Completed

Psychosis

Institutions:

Canada

Toronto Centre for Addiction and Mental Health, and University of Toronto Department of Psychiatry

Investigators:

Kidd SA, Herman Y, Virdee G, Bowie CR, Velligan D, Plagiannakos C, Voineskos A.

Size:

56 Participants

Trial Registration:

See Registration

Publication:

Kidd SA, Herman Y, Virdee G, et al. A comparison of compensatory and restorative cognitive interventions in early psychosis. Schizophr Res Cogn. 2019;19:100157. Published 2019 Jul 24. doi:10.1016/j.scog.2019.100157

–

2015
2018

Evaluation of Dallas Metrocare’s Enhanced Program for Early Psychosis (ePEP)

Completed

Psychosis

Institutions:

USA

UT Southwestern Medical Center

Investigators:

Carol North, Ana Stan, Debra Bushong, Draper Bushanan

Size:

90 Participants

Presentation:

Presentation

–

2015
2020

The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial

Completed

Psychosis

Institutions:

Denmark

Psychiatric Center Copenhagen

Investigators:

Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft

Size:

126 Participants

Trial Registration:

See Registration

Publication:

Glenthøj LB, Fagerlund B, Randers L, et al. The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial. Trials. 2015;16:25. Published 2015 Jan 27. doi:10.1186/s13063-014-0542-8

–

2014
2017

Motivation and engagement during cognitive training for schizophrenia spectrum disorders

Completed

Schizophrenia

Institutions:

Canada

Department of Psychology, Queen’s University, Kingston, ON

Investigators:

Michael W.Best, Melissa Milanovic, Tanya Tran, Pauline Leung, Robyn Jackowich, Stéphanie Gauvin, Talia Leibovitz, Christopher R.Bowie

Size:

38 Participants

Publication:

Best MW, Milanovic M, Tran T, et al. Motivation and engagement during cognitive training for schizophrenia spectrum disorders. Schizophr Res Cogn. 2019;19:100151. Published 2019 May 23. doi:10.1016/j.scog.2019.100151

–

2014
2019

Manualized group cognitive-behavioral therapy for social anxiety in first episode psychosis: A randomized controlled trial

In Progress

Psychosis

Institutions:

Canada

Douglas Mental Health University Insitute, Montreal, QC & Department of Psychiatry, McGill University, Montréal QC

Investigators:

Martin Lepage, Ashol K. Malla, Philippe-Olivier Harvey, Christopher Bowie

Size:

120 Participants

Trial Registration:

See Registration

–

2014
2019

Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia

In Progress

Schizophrenia

Institutions:

Canada

University of British Columbia

Investigators:

Todd Woodward

Size:

75 Participants

–

2014
2016

Cognitive Training protocols in people with Chronic Pain

Completed

Chronic Pain

Institutions:

Australia

School of Psychological Sciences, Monash University; and Caufiled Pain Management and Research Center, Caulfield Hospital

Investigators:

Melita Giummarra, Nellie Georgiou-Karistianis, Stephen Gibson, Katharine Baker

Size:

50 Participants

Publication:

Baker KS, Georgiou-Karistianis N, Lampit A, Valenzuela M, Gibson SJ, Giummarra MJ. (2018) Computerised training improves cognitive performance in chronic pain: a participant-blinded randomised active-controlled trial with remote supervision. Pain, 2018 jan. doi: 10.1097/j.pain.0000000000001150

–

2014
2016

Individualized Metacognitive Training (MCT+) Reduces Delusional Symptoms in Psychosis: A Randomized Clinical Trial

Completed

Psychosis

Institutions:

Australia

School of Psychology, Flinders University, Adelaide, SA

Investigators:

Ryan Balzan

Size:

70 Participants

Publication:

Balzan RP, Mattiske JK, Delfabbro P, Liu D, Galletly C. Individualized Metacognitive Training (MCT+) Reduces Delusional Symptoms in Psychosis: A Randomized Clinical Trial. Schizophr Bull. 2019;45(1):27‐36. doi:10.1093/schbul/sby152

–

2014
2015

Facilitating success for people with mental health issues in a college through cognitive remediation therapy and social and emotional learning

Completed

Mental Health

Academic Success

Institutions:

Canada

CPLS – George Brown College – Saint James Campus – Toronto, Department of Medical Sciences – University of Western Ontario

Investigators:

Jaswant Kaur Bajwa, Alex Irwin

Size:

21 Participants

Publication:

Bajwa, J.K., Bajwa, B. and Gula, T. (2019), “Facilitating success for people with mental health issues in a college through cognitive remediation therapy and social and emotional learning”, Journal of Research in Innovative Teaching & Learning, Vol. 12 No. 2, pp. 164-182.

–

2014
2017

Cognitive training to improve language comprehension for seniors?

Completed

Geriatrics

Institutions:

Germany

Jean-Uhrmacher Institut für klinische HNO-Forschung, Klinik und Poliklinik für Neurologie der Uniklinik Köln, Lehrstuhl für Pädagogik und Didaktik hörgeschädigter Menschen

Investigators:

Magdalene Ortmann, Harmut Meister, Josef Kessler, Thomas Kaul

Size:

50 Participants

Publication:

No Publication

–

2013
2015

Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia

Completed

Schizophrenia

Social Cognition

Institutions:

Canada

McGill University Psychiatry Department

Investigators:

Philippe-Olivier Harvey, Martin Lepage, Vickie Auclair

Size:

40 Participants

Publication:

No publication

–

2013
2014

Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study

Completed

Hoarding Disorder

Institutions:

Canada

University of British Columbia

Investigators:

Jennifer DiMauro

Size:

17 Participants

Publication:

Jennifer DiMauro, Marla Genova, David F. Tolin, Matthew M. Kurtz, Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study, Journal of Obsessive-Compulsive and Related Disorders, Available online 2 April 2014, ISSN 2211-3649.

–

2012

Conditions for Maximizing Effects of 90 Days of Brain Training

Completed

General Population

Institutions:

France

Scientific Brain Training

Investigators:

Franck Tarpin-Bernard, Bernard Croisile

Size:

350 Participants

Publication:

Tarpin-Bernard F, Croisile, B. Conditions for Maximizing Effects of 90 Days of Brain Training. Unpublished

–

2011
2013

Action-based cognitive remediation for individuals with serious mental illnesses: Effects of real-world simulations and goal setting

Completed

SMI

Institutions:

Canada

Queen’s University, Kingston, ON

Investigators:

Christopher Bowie

Size:

50 Participants

Publication:

Bowie CR, Grossman M, Gupta M, Holshausen K, Best MW. Action-based cognitive remediation for individuals with serious mental illnesses: Effects of real-world simulations and goal setting on functional and vocational outcomes. Psychiatr Rehabil J. 2017;40(1):53‐60. doi:10.1037/prj0000189

–

2011

Increased employability of the unemployed aged 50+ through cognitive training?

Completed

Employment

Institutions:

Germany

Jacobs Center on Lifelong Learning & Research Institutional Development, Jacobs University Bremen

Investigators:

B. Godde, C. M. G. Noack, C. Windisch & C. Voelcker-Rehage

Size:

87 Participants

Presentation:

Presentation

Publication:

Godde, Ben & Noack, C. Martin G. & Niemann, Claudia & Voelcker-Rehage, Claudia. (2012). Increased employability of the unemployed aged 50+ through cognitive training?. 10.13140/RG.2.1.2327.0481.

–

2010
2011

Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia

Completed

Schizophrenia

Institutions:

Canada

Queen’s University, Kingston, ON

Investigators:

Christopher Bowie

Size:

30 Participants

Publication:

Bowie CR, McGurk SR, Mausbach B, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real-world behavior. Am J Psychiatry. 2012;169(7):710‐718. doi:10.1176/appi.ajp.2012.11091337

–

2007

Alzheimer’s patients maintain cognitive skills and improve self confidence

Completed

Alzheimer’s Disease

Institutions:

France

Sophia’s Gardens, Alzheimer’s disease clinic, Castelnau-le-Lez

Investigators:

Dr. Foare

Size:

47 Participants

Presentation:

Sophia’s Gardens: AD patients maintain cognitive skills and improve self confidence

–

2007

Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans

Completed

General Population

fMRI

Institutions:

USA

Johnny Orr Memory Center, Iowa Health System, Funded by the Center for Disease Control

Investigators:

Robert Bender III, David Michael, Derek Campbell, Charles DePena

Presentation:

Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans

–

2006
2008

Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia.

Completed

Schizophrenia

Institutions:

Switzerland

Lausanne Hospital

Investigators:

Pascal Vianin

Size:

28 Participants

Publication:

Vianin, Pascal & Deppen, Patricia & Croisile, Bernard & Tarpin-Bernard, Franck & Sarrazin-Bruchez, P. & Dukes, R. & Grillon, M.L.. (2010). Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. J Cogn Rehabil. 28.

–

2006

Memory Stimulation. Which scientific benefits? Which exercises?

Completed

Geriatrics

Institutions:

France

Scientific Brain Training

Investigators:

Bernard Croisile et al

Size:

39 Participants

Publication:

Croile B et al.Geriatrics Review’ 2006;31:421-433 France

–

2001
2002

Transferability of Cognitive Training to every-day activities (AKA King 64)

Completed

Children

Institutions:

France

EMC laboratory (Université Lyon II – CNRS)

Investigators:

Michel Noir, Ph.D

Size:

117 Participants

Publication:

Thesis

–

Treating Brain Injuries in Colorado

HappyNeuron Pro is very elegant because it actually pinpoints cognitive areas and it gives really strong stimulus items and that’s how you actually build cognitive functions.

Dr. Mary Ann Keatley, Ph.D., CCC,
Brain Injury Hope Foundation

Bridging the Brain and the Classroom

Every kid needs to be doing HappyNeuron Pro. Every school needs to be working on these skills. Every school in America should have a cognitive skill curriculum.

Kyra Minichan, M.A., CCC-SLP
The Cognitive Emporium

Personalizing Brain Injury Support

HappyNeuron Pro has allowed us to have a structure so we could underpin the client’s day and start their day with it. HappyNeuron Pro allowed us to engage with clients by allowing us to look at their scores and have a conversation around that.

Natalie Mackenzie, MSc, CPCRT, CBIST
BIS Services (Brain Injury Support + Cognitive Rehabilitation)