Research and Clinical Studies

In addition to the general body of brain research, HAPPYneuron’s scientific team in partnership with prestigious research institutions have studied the effectiveness of the exercises in a variety of conditions. Research has also shown our programs may be effective in improving cognitive symptoms related to a number of different conditions. Below is a sample list.

Study

Size

Research Institution

Investigator

Status

2016-2018: Translational Neuroscience Optimization of GlyT1 Inhibitor
80 participants
Yale University
John H. Krystal, M.D.
In progress

Study

 

Size

Research Institution

Investigator

Status

2016-2017: Exploring cognitive training as a non-pharmaceutical therapeutic intervention for people with Huntington’s disease
8 participants
Cardiff University in the Cardiff Huntington’s Disease Research Centre
Emma Yhnell, Pr Anne Rosser
In progress

Study

Size

Research Institution

Investigator

Status

2016-2017: Neural bases of intrinsic motivation for learning in individuals at clinical high risk (CHR) for psychosis
12 participants
Olin Neuropsychiatry Research Center, the Institute of Living at Hartford Hospital
Jimmy Choi, Godfrey Pearlson, Michael Stevensn Joanna M. Fiszdon
In progress

Study

 

Size

Research Institution

Investigator

Status

2016-2017: Cognitive training program on verbal memory in older women who are within a year of having undergone chemotherapy treatment for early‐stage breast cancer
40 participants
Rehabilitation Institute of Chicago, Northwestern Feinberg School of Medicine
Leora R. Cherney, Diane F. Morean, Alyx Kesselring
In progress

Study

Size

Research Institution

Investigator

Status

2016: CBT for psychosis in combination with Cognitive Remediation
40 participants
Addictions & Mental Health Services – Kingston Frontenac Lennox & Addington
Dr. Farooq Naeem, Dr. Tariq Munshi, Dr. Muhammad Ayub, Dr. Rupy Johal
In progress

Study

Size

Research Institution

Investigator

Status

2016: Evaluation of cognitive tele-rehabilitation program for children with Attention Deficit Hyperactivity Disorder
100 participants
Bio functional Studies Institute – Universidad Complutense (Madrid)
Elimelech Duarte, Jesus Alvarado, Alejandra Koeneke
In progress

Study

Size

Research Institution

Investigator

Status

2015-2018: Cognitive and Physical Training in Elderly: Behavioral and EEG study
120 participants
Laboratoire d’Study des mecanismes Cognitifs, Université Lumière Lyon 2, France
Clémence Joubert (Ph. D student) & Hanna Chainay. Ph. D.

In progress

Study

Size

Research Institution

Investigator

Status

2015-2017: Evaluation of Dallas Metrocare’s Enhanced Program for Early Psychosis (ePEP)
90 participants
UT Southwestern Medical Center
Carol North, Ana Stan, Debra Bushong, Draper Bushanan
In progress

Study

Research Institution

Investigator

Status

2015-2016: Measuring the effectiveness of Cognitive Remediation on Schizophrenia and Depression 
National Center of Neurology and Psychiatry, Japan
Kazuyuki Nakagome, M.D., Ph.D.
In progress

Study

 

Size

Research Institution

Investigator

Status

2014-2019: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia. 
75 participants
University of British Columbia
Todd Woodward, Ph.D.
In progress

Study

 

Size

Research Institution

Investigator

Status

2014-2018: Manualized group cognitive-behavioral therapy for social anxiety in first episode psychosis: A randomized controlled trial
120 participants
Douglas Mental Health University Insitute, Montreal, QC & Department of Psychiatry, McGill University, Montréal QC
Dr Martin Lepage, Ashol K. Malla, Dr Philippe-Olivier Harvey, Dr. Christopher Bowie
In progress

Study

 

Size

Research Institution

Investigator

Status

2014-2018: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia.
75 participants
University of British Columbia
Todd Woodward, Mahesh Menon, Devon Andersen
In progress

Study

 

Size

Research Institution

Investigator

 

Status

Publication

2014-2017: The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial
126 participants
Psychiatric Center Copenhagen, Denmark
Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft.
In progress
BioMed Central, Trials. 2015; 16: 25 (Description of Trial)

Study

 

Size

Research Institutions

Investigator

Status

2014-2016: Cognitive Training protocols in people with Chronic Pain
50 participants
School of Psychological Sciences, Monash University; and Caufiled Pain Management and Research Center, Caulfield Hospital
Dr. Melita Giummarra, Pr. Nellie Georgiou-Karistianis, Pr. Stephen Gibson, Katharine Baker
In progress

Study

 

Research Institutions

Investigator

Status

2014-2016: Comparing interventions that have either been designed to target the positive symptoms (particularly delusions) or the cognitive symptoms (e.g., memory and language deficits) of Schizophrenia
School of Psychology, Flinders University, Adelaide, SA, Australia
Dr Ryan Balzan
In progress

Study

 

Size

Research Institutions

Investigator

Status

2014-2015: Preparing people marginalized by mental health issues for further education/ employment through Education 
25 participants
George Brown College
Jaswant Kaur Bajwa, Alex Irwin
In progress

Study

Size

Research Institution

Investigator

Status

Publication

2014: Increased activation in Broca’s area after cognitive remediation in schizophrenia 
16 participants
Lausanne Hospital, Switzerland
Pascal Vianin, Ph.D., Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey
Completed
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca’s area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209. Click Here to Get an Electronic Copy

Study

Research Institution

Investigator

Status

2014: Remote Cognitive Remediation for Psychosis 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
In progress

Study

Research Institution

Investigator

Status

2014: Cognitive Remediation for Geriatric Schizophrenia 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
In progress

Study

Research Institution

Investigator

Status

2014: Short-term, Intensive Executive Functioning Training with an Active Placebo 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
In progress

Study

Research Institution

Investigator

Status

2014: Remote Cognitive Remediation for Acutely Hospitalized Depression 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
In progress

Study

Size

Research Institution

 

Investigator

Status

Presentation

2014: Cognitive training to improve language comprehension for seniors? 
50 participants – under recruitment
Jean-Uhrmacher Institut für klinische HNO-Forschung, Klinik und Poliklinik für Neurologie der Uniklinik Köln, Lehrstuhl für Pädagogik und Didaktik hörgeschädigter Menschen
Dr. Magdalene Ortmann, Prof. Dr. Harmut Meister, Prof. Dr. Josef Kessler, Prof. Dr. Thomas Kaul
In progress
Abstract and contact to be recruited

Study

Research Institution

Investigator

Status

2013-2015: Efficacy of psychological treatments for schizophrenia 
School of Psychology, Flinders University, Adelaide, SA, Australia
Dr Ryan Balzan
In progress

Study

Research Institution

Investigator

Status

2013-2015: Scanning Training Rehabilitation for Visual Field Loss after stroke at Home: The STaRFiSH Study 
Glasgow Caledonian University
Christine Hazelton, Dr. Alex Pollock
In progress

Study

Size

Research Institution

Investigator

Status

2013-2015: Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia 
30 to 40 participants
McGill University Psychiatry Department Philippe-Olivier Harvey
In progress

Study

Size

Research Institution

Investigator

Status

Publication

2013-2014: Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study 
17 participants
University of British Columbia
Jennifer DiMauro
Completed
Jennifer DiMauro, Marla Genova, David F. Tolin, Matthew M. Kurtz, Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study, Journal of Obsessive-Compulsive and Related Disorders, Available online 2 April 2014, ISSN 2211-3649.

Study

 

Size

Research Institution

Investigator

Status

Presentation

2012-2015: Identifying neuropsychological subgroups in patients with bipolar disorder and evaluation of a cognitive remediation program 
190 participants
Universitätsklininkum Würzburg
Julia Volkert, Supervisor: Prof. Dr. Andreas Reif
In progress
Identifying neuropsychological subgroups in patients with bipolar disorder and evaluation of a cognitive remediation program

Study

Size

Research Institution

Investigator

Status

Publication

2012: Conditions for Maximizing Effects of 90 Days of Brain Training 
350 participants
Scientific Brain Training
Franck Tarpin-Bernard, Ph.D.Bernard Croisile, M.D., Ph.D.
Completed
Conditions for Maximizing Effects of 90 Days of Brain Training

Study

Size

Research Institution

Investigator

Status

2011-2013: Neurocognitive Enhancement in a Vocational Services Program 
60 participants
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
In progress

Study

Research Institution

Investigator

Status

Publication

2011-2013: Cognitive Remediation for Treatment Resistant Depression 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
Completed
Bowie CR, Gupta M, Holshausen K, Jokic R, Best, M, Milev, R. Cognitive remediation for treatment resistant depression: Effects on cognition and functioning and the role of online homework. Journal of Nervous and Mental Disorders, 2013, 201, 680-685.

Study

Size

Research Institution

Investigator

Status

Publication

2011: Increased employability of the unemployed aged 50+ through cognitive training? 
87 participants
Jacobs Center on Lifelong Learning & Research Institutional Development, Jacobs University Bremen, Germany
B. Godde, C. M. G. Noack, C. Windisch & C. Voelcker-Rehage
Completed
Increased employability of the unemployed aged 50+ through cognitive training?

Study

Size

Research Institution

Investigator

Funded by

Status

Présentation

Publication

2010-2011: Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia 
30 participants
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
NARSAD
Completed
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Bowie CR, McGurk SM, Mausbach BT, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real world behavior. American Journal of Psychiatry, 2012, 1-9

Study

Size

Research Institution

Investigator

Status

Publication

2009-2011: Intensive Spatial Memory Training for older Adults 
40 participants
University of Zurich, Institute of Psychology, Gerontopsychology
Anne Eschen, Ph.D.
Completed
In progress

Study

Size

Research Institution

Investigator

Status

Présentation

Publication

2009-2011: Neurocognitive Enhancement Therapy for Major Depressive Disorder 
40 participants
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
Completed 
Poster at Cognitive Remediation Conference 2011
, New York, June 2011
In progress

Study

Size

Research Institution

Investigator

Funded by

Status

Présentation

Publication

2009: Specificity and Generalizability of Cognitive Remediation and Functional Skills Training in Schizophrenia 
83 participants
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
NARSAD
Completed
Cognitive Remediation in Psychiatry Conference, New York, June 2010 on
In progress

Study

Size

Research Institution

 

Investigator

 

Status

Présentation

 

Publication

2008-2012: Cognitive rehabilitation for depressed patients 
30 participants
French National Science Research Center

Paris 6 University at La Pitié-Salpêtriére Hospital
Diane Samama, Ouriel Grynszpan, Ph.D., Odile Komano, Fernando Perez Diaz, Julie Guertault, Franck Tarpin-Bernard, Ph.D., Pr. Roland Jouvent.
Completed
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Poster at Cognitive Remediation Conference 2012, New York, June 2012
In progress

Study

Size

Investigator

Funded by

Status

Présentation

Publication

2008-2011: Cognitive remediation effectiveness for schizophrenic patients
280 participants multi-site
Nicolas Franck, Institute for Cognitive Science, Lyon, France
Funded by PHRC (French Government Funding Program for Clinical Research)
Completed
Poster at 9th World Congress of Biological Psychiatry, Paris, France, July 2009
Franck, N. et al. (2013). Specific vs general cognitive remediation for schizophrenia: a multicentre randomised trial. Schizophrenia Research, 147(1), pp. 68-74. Click Here to Get an Electronic Copy

Study

Size

Investigator

Status

Results

Publication

2008: Cognitive Training Improves Driving Skills 
90 participants
Bernard Croisile, M.D., Ph.D., Gilles Reilhac, Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D.
Completed
Subjects demonstrate an average of 14% improvement in key skills
Brain Training Influence on Cognitive Function Effectiveness at Boiron Labs

Study

Size

Investigator

 

Status

Results

Publication

2008: Benefits of Online Cognitive Training 
217 participants
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Diana Miner, M.A., M.S., Gaël Allain, Ph.D.
Completed
Subjects demonstrate +8.5% average improvement
In progress

Study

Size

Investigator

Status

Présentation

2007: Alzheimer’s patients maintain cognitive skills and improve self confidence 
47 participants
Dr. Foare, Sophia’s Gardens, Alzheimer’s disease clinic, Castelnau-le-Lez, France
Completed
Sophia’s Gardens: AD patients maintain cognitive skills and improve self confidence

Study

Size

Investigator

Status

Results

Publication

2007: Online Cognitive Training Improves Cognitive Performance 
85 participants
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Gaël Allain, Ph.D.
Completed
85 HAPPYneuron Users show +16% average improvement in 18 weeks

Online Cognitive Training Improves Cognitive Performance
National Academy of Neuropyschology Poster
American Society on Aging & National Council on Aging Conference Poster

Study

Investigator

Funded by

Status

Results

Publication

2007: Significant Brain Activity Improvement 
Robert Bender III, M.D., D.Michael
The Center for Disease Control (CDC)
Completed
“Shows Significant Brain Activity Improvement. HAPPYneuron™ Games Key Component of Brain Wellness Program”

Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans
CDC-Funded Pilot Study Shows Significant Brain Activity Improvement

Study

Size

Research Institution

Investigator

Funded by

Status

Présentation

Publication

2006-2008: Rehabilitation software program for schizophrenia patients 
28 participants
Lausanne Hospital, Switzerland
Pascal Vianin, Ph.D.
CHUV (Centre Hospitalier Universitaire Vaudois)
Completed
Cognitive Remediation Conference, NYC, June 2009 – poster
Vianin, P., Deppen, P., Croisile, B., Tarpin-Bernard, F., Sarrasin-Bruchez, P., Dukes, R., Grillon, M. Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. The Journal of Cognitive Rehabilitation, NeuroScience Publishers, Volume 28. Fall 2010, pp 11-21, Click Here to Get an Electronic Copy

Study

Size

Investigator

Status

Results

Publication

2006: Memory Stimulation. Which scientific benefits? Which exercises? 
39 participants
Bernard Croisile, M.D., Ph.D. et al
Completed
HAPPYneuron Users show +12% average improvement in 18 weeks
Geriatrics Review’ 2006;31:421-433 France

Study

 

Research Institution

Investigator

Funded by

Status

Présentation

 

Publication

2004-2006: MNESIS Project – Using the internet as a means of social integration and cognitive stimulation in a residential unit for elderlies 
Lyon 2 University, Lyon INSA (ICTT), Medica-France
Michel C., Bobillier-Chaumon M.-E., Cohen-Montandreau V., Tarpin-Bernard F.
French Ministry of Industry
Completed
Elderlies in residential home care units. Can ICT be considered as a social rebinding method? In Conférence EUTIC 2006
Marc-Eric Bobillier Chaumon, Christine Michel, Franck Tarpin Bernard & Bernard Croisile , Behaviour & Information Technology (2013): Can ICT improve the quality of life of elderly adults living in residential home care units? From actual impacts to hidden artefacts, Behaviour & Information Technology, pp 1-17. Click Here to Get an Electronic Copy

Study

Size

Research Institution

Investigator

Status

Results

Publication

2003-2006: The Importance of Memory and Concentration Skills for Schoolchildren 
130 participants school children ages 10 and 11, over a 3 year time frame
City of Elancourt, France ; Association Initiatives Terrain, France ; Lille University, France
Neukirch A., Fenouillet F., Hildebrandt R.
Completed
Better CMS score and various effects on recognition tasks.
In progress

Study

Size

Research Institution

Investigator

Status

Results

Publication

2001-2002: Transferability of Cognitive Training to every-day activities (AKA King 64)
117 participants children, 10 years old
EMC laboratory (Université Lyon II – CNRS), France
Michel Noir, Ph.D
Completed
Average of 40% + improvements in various cognitive skills performance
Thesis of M. Noir Pg.D (french)

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Page last updated on Feb 27,2017

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