Etudes scientifiques

En plus du corpus existant de recherches sur le cerveau, l’équipe scientifique de HAPPYneuron Pro, en partenariat avec de prestigieux instituts de recherche, a étudié l’efficacité des exercices sur de multiples pathologies. La recherche et les études cliniques ont montré l’efficacité des exercices, modules et programmes dans l’amélioration des symptômes cognitifs dans de nombreuses pathologies. Voici quelques exemples d’études ci-dessous.

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2016-2018: Translational Neuroscience Optimization of GlyT1 Inhibitor
80 sujets
Yale University
John H. Krystal, M.D.
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2016-2017: Exploring cognitive training as a non-pharmaceutical therapeutic intervention for people with Huntington’s disease
8 sujets
Cardiff University in the Cardiff Huntington’s Disease Research Centre
Emma Yhnell, Pr Anne Rosser
En cours

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2016-2017: Neural bases of intrinsic motivation for learning in individuals at clinical high risk (CHR) for psychosis
12 sujets
Olin Neuropsychiatry Research Center, the Institute of Living at Hartford Hospital
Jimmy Choi, Godfrey Pearlson, Michael Stevensn Joanna M. Fiszdon
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2016-2017: Cognitive training program on verbal memory in older women who are within a year of having undergone chemotherapy treatment for early‐stage breast cancer
40 sujets
Rehabilitation Institute of Chicago, Northwestern Feinberg School of Medicine
Leora R. Cherney, Diane F. Morean, Alyx Kesselring
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2016: CBT for psychosis in combination with Cognitive Remediation
40 sujets
Addictions & Mental Health Services – Kingston Frontenac Lennox & Addington
Dr. Farooq Naeem, Dr. Tariq Munshi, Dr. Muhammad Ayub, Dr. Rupy Johal
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2016: Evaluation of cognitive tele-rehabilitation program for children with Attention Deficit Hyperactivity Disorder
100 sujets
Bio functional Studies Institute – Universidad Complutense (Madrid)
Elimelech Duarte, Jesus Alvarado, Alejandra Koeneke
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2015-2018: Cognitive and Physical Training in Elderly: Behavioral and EEG study
120 sujets
Laboratoire d’Etude des mecanismes Cognitifs, Université Lumière Lyon 2, France
Clémence Joubert (Ph. D student) & Hanna Chainay. Ph. D.

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2015-2017: Evaluation of Dallas Metrocare’s Enhanced Program for Early Psychosis (ePEP)
90 sujets
UT Southwestern Medical Center
Carol North, Ana Stan, Debra Bushong, Draper Bushanan
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2015-2016: Measuring the effectiveness of Cognitive Remediation on Schizophrenia and Depression 
National Center of Neurology and Psychiatry, Japan
Kazuyuki Nakagome, M.D., Ph.D.
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2014-2019: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia. 
75 sujets
University of British Columbia
Todd Woodward, Ph.D.
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2014-2018: Manualized group cognitive-behavioral therapy for social anxiety in first episode psychosis: A randomized controlled trial
120 sujets
Douglas Mental Health University Insitute, Montreal, QC & Department of Psychiatry, McGill University, Montréal QC
Dr Martin Lepage, Ashol K. Malla, Dr Philippe-Olivier Harvey, Dr. Christopher Bowie
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2014-2018: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia.
75 sujets
University of British Columbia
Todd Woodward, Mahesh Menon, Devon Andersen
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2014-2017: The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial
126 sujets
Psychiatric Center Copenhagen, Denmark
Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft.
En cours
BioMed Central, Trials. 2015; 16: 25 (Description of Trial)

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2014-2016: Cognitive Training protocols in people with Chronic Pain
50 sujets
School of Psychological Sciences, Monash University; and Caufiled Pain Management and Research Center, Caulfield Hospital
Dr. Melita Giummarra, Pr. Nellie Georgiou-Karistianis, Pr. Stephen Gibson, Katharine Baker
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2014-2016: Comparing interventions that have either been designed to target the positive symptoms (particularly delusions) or the cognitive symptoms (e.g., memory and language deficits) of Schizophrenia
School of Psychology, Flinders University, Adelaide, SA, Australia
Dr Ryan Balzan
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2014-2015: Preparing people marginalized by mental health issues for further education/ employment through Education 
25 sujets
George Brown College
Jaswant Kaur Bajwa, Alex Irwin
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2014: Increased activation in Broca’s area after cognitive remediation in schizophrenia 
16 sujets
Lausanne Hospital, Switzerland
Pascal Vianin, Ph.D., Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey
Terminée
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca’s area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209. Click Here to Get an Electronic Copy

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2014: Remote Cognitive Remediation for Psychosis 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
En cours

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2014: Cognitive Remediation for Geriatric Schizophrenia 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
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2014: Short-term, Intensive Executive Functioning Training with an Active Placebo 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
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2014: Remote Cognitive Remediation for Acutely Hospitalized Depression 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
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2014: Cognitive training to improve language comprehension for seniors? 
50 sujets – under recruitment
Jean-Uhrmacher Institut für klinische HNO-Forschung, Klinik und Poliklinik für Neurologie der Uniklinik Köln, Lehrstuhl für Pädagogik und Didaktik hörgeschädigter Menschen
Dr. Magdalene Ortmann, Prof. Dr. Harmut Meister, Prof. Dr. Josef Kessler, Prof. Dr. Thomas Kaul
En cours
Abstract and contact to be recruited

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2013-2015: Efficacy of psychological treatments for schizophrenia 
School of Psychology, Flinders University, Adelaide, SA, Australia
Dr Ryan Balzan
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2013-2015: Scanning Training Rehabilitation for Visual Field Loss after stroke at Home: The STaRFiSH Study 
Glasgow Caledonian University
Christine Hazelton, Dr. Alex Pollock
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2013-2015: Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia 
30 à 40 sujets
McGill University Psychiatry Department Philippe-Olivier Harvey
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2013-2014: Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study 
17 sujets
University of British Columbia
Jennifer DiMauro
Terminée
Jennifer DiMauro, Marla Genova, David F. Tolin, Matthew M. Kurtz, Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study, Journal of Obsessive-Compulsive and Related Disorders, Available online 2 April 2014, ISSN 2211-3649.

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2012-2015: Identifying neuropsychological subgroups in patients with bipolar disorder and evaluation of a cognitive remediation program 
190 sujets
Universitätsklininkum Würzburg
Julia Volkert, Supervisor: Prof. Dr. Andreas Reif
En cours
Identifying neuropsychological subgroups in patients with bipolar disorder and evaluation of a cognitive remediation program

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2012: Conditions for Maximizing Effects of 90 Days of Brain Training 
350 sujets
Scientific Brain Training
Franck Tarpin-Bernard, Ph.D.Bernard Croisile, M.D., Ph.D.
Terminée
Conditions for Maximizing Effects of 90 Days of Brain Training

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2011-2013: Neurocognitive Enhancement in a Vocational Services Program 
60 sujets
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
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2011-2013: Cognitive Remediation for Treatment Resistant Depression 
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
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Bowie CR, Gupta M, Holshausen K, Jokic R, Best, M, Milev, R. Cognitive remediation for treatment resistant depression: Effects on cognition and functioning and the role of online homework. Journal of Nervous and Mental Disorders, 2013, 201, 680-685.

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2011: Increased employability of the unemployed aged 50+ through cognitive training? 
87 sujets
Jacobs Center on Lifelong Learning & Institutional Development, Jacobs University Bremen, Germany
B. Godde, C. M. G. Noack, C. Windisch & C. Voelcker-Rehage
Terminée
Increased employability of the unemployed aged 50+ through cognitive training?

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2010-2011: Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia 
30 sujets
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
NARSAD
Terminée
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Bowie CR, McGurk SM, Mausbach BT, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real world behavior. American Journal of Psychiatry, 2012, 1-9

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2009-2011: Intensive Spatial Memory Training for older Adults 
40 sujets
University of Zurich, Institute of Psychology, Gerontopsychology
Anne Eschen, Ph.D.
Terminée
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2009-2011: Neurocognitive Enhancement Therapy for Major Depressive Disorder 
40 sujets
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
Terminée 
Poster at Cognitive Remediation Conference 2011
, New York, June 2011
Pending

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2009: Specificity and Generalizability of Cognitive Remediation and Functional Skills Training in Schizophrenia 
83 sujets
Queen’s University, Kingston, ON, Canada
Christopher Bowie, Ph.D.
NARSAD
Terminée
Cognitive Remediation in Psychiatry Conference, New York, June 2010 on
Pending

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2008-2012: Cognitive rehabilitation for depressed patients 
30 sujets
French National Science Research Center

Paris 6 University at La Pitié-Salpêtriére Hospital
Diane Samama, Ouriel Grynszpan, Ph.D., Odile Komano, Fernando Perez Diaz, Julie Guertault, Franck Tarpin-Bernard, Ph.D., Pr. Roland Jouvent.
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Poster at Cognitive Remediation Conference 2011, New York, June 2011
Poster at Cognitive Remediation Conference 2012, New York, June 2012
Pending

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2008-2011: Cognitive remediation effectiveness for schizophrenic patients
280 sujets multi-site
Nicolas Franck, Institute for Cognitive Science, Lyon, France
Funded by PHRC (French Government Funding Program for Clinical Research)
Terminée
Poster at 9th World Congress of Biological Psychiatry, Paris, France, July 2009
Franck, N. et al. (2013). Specific vs general cognitive remediation for schizophrenia: a multicentre randomised trial. Schizophrenia Research, 147(1), pp. 68-74. Click Here to Get an Electronic Copy

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2008: Cognitive Training Improves Driving Skills 
90 sujets
Bernard Croisile, M.D., Ph.D., Gilles Reilhac, Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D.
Terminée
Subjects demonstrate an average of 14% improvement in key skills
Brain Training Influence on Cognitive Function Effectiveness at Boiron Labs

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2008: Benefits of Online Cognitive Training 
217 sujets
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Diana Miner, M.A., M.S., Gaël Allain, Ph.D.
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Subjects demonstrate +8.5% average improvement
Pending

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2007: Alzheimer’s patients maintain cognitive skills and improve self confidence 
47 sujets
Dr. Foare, Sophia’s Gardens, Alzheimer’s disease clinic, Castelnau-le-Lez, France
Terminée
Sophia’s Gardens: AD patients maintain cognitive skills and improve self confidence

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2007: Online Cognitive Training Improves Cognitive Performance 
85 sujets
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Gaël Allain, Ph.D.
Terminée
85 HAPPYneuron Users show +16% average improvement in 18 weeks

Online Cognitive Training Improves Cognitive Performance
National Academy of Neuropyschology Poster
American Society on Aging & National Council on Aging Conference Poster

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2007: Significant Brain Activity Improvement 
Robert Bender III, M.D., D.Michael
The Center for Disease Control (CDC)
Terminée
“Shows Significant Brain Activity Improvement. HAPPYneuron™ Games Key Component of Brain Wellness Program”

Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans
CDC-Funded Pilot Study Shows Significant Brain Activity Improvement

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2006-2008: Rehabilitation software program for schizophrenia patients 
28 sujets
Lausanne Hospital, Switzerland
Pascal Vianin, Ph.D.
CHUV (Centre Hospitalier Universitaire Vaudois)
Terminée
Cognitive Remediation Conference, NYC, June 2009 – poster
Vianin, P., Deppen, P., Croisile, B., Tarpin-Bernard, F., Sarrasin-Bruchez, P., Dukes, R., Grillon, M. Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. The Journal of Cognitive Rehabilitation, NeuroScience Publishers, Volume 28. Fall 2010, pp 11-21, Click Here to Get an Electronic Copy

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2006: Memory Stimulation. Which scientific benefits? Which exercises? 
39 sujets
Bernard Croisile, M.D., Ph.D. et al
Terminée
HAPPYneuron Users show +12% average improvement in 18 weeks
Geriatrics Review’ 2006;31:421-433 France

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2004-2006: MNESIS Project – Using the internet as a means of social integration and cognitive stimulation in a residential unit for elderlies 
Lyon 2 University, Lyon INSA (ICTT), Medica-France
Michel C., Bobillier-Chaumon M.-E., Cohen-Montandreau V., Tarpin-Bernard F.
French Ministry of Industry
Terminée
Elderlies in residential home care units. Can ICT be considered as a social rebinding method? In Conférence EUTIC 2006
Marc-Eric Bobillier Chaumon, Christine Michel, Franck Tarpin Bernard & Bernard Croisile , Behaviour & Information Technology (2013): Can ICT improve the quality of life of elderly adults living in residential home care units? From actual impacts to hidden artefacts, Behaviour & Information Technology, pp 1-17. Click Here to Get an Electronic Copy

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2003-2006: The Importance of Memory and Concentration Skills for Schoolchildren 
130 sujets school children ages 10 and 11, over a 3 year time frame
City of Elancourt, France ; Association Initiatives Terrain, France ; Lille University, France
Neukirch A., Fenouillet F., Hildebrandt R.
Terminée
Better CMS score and various effects on recognition tasks.
Pending

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2001-2002: Transferability of Cognitive Training to every-day activities (AKA King 64)
117 sujets children, 10 years old
EMC laboratory (Université Lyon II – CNRS), France
Michel Noir, Ph.D
Terminée
Average of 40% + improvements in various cognitive skills performance
Thesis of M. Noir Pg.D (french)

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Page mise à jour le 23/02/2017